Enhancement of enantioselectivity by altering alcohol concentration for esterification in supercritical CO2

This work used Candida rugosa lipase to resolve racemic Naproxen by esterif ication with ethanol, n-butanol, n-hexanol, or n-decanol in supercritical C O2, It was found that the lipase enantioselectively, esterified (S)-Naproxe n within all systems. The enantiomeric ratio increased four folds by slight ly decreasing the alcohol concentration, The ef feet of the alcohol concent ration on the enantioselectivity was greater than that of changing acyl acc epters.