Clinical evaluation of Bio-Oss (R): a bovine-derived xenograft for the treatment of periodontal osseous defects in humans

The purpose of this study was to compare the bovine derived xenograft (BDX) Bio-Oss(R) to demineralized freeze dried bone allograft (DFDBA) in human i ntrabony defects. 17 healthy patients with no systemic disease with moderat e-severe periodontitis (7 males, 10 females; aged 34-67), were treated. Sur gically, defects were included only if the intraosseous defect depth was >3 .0 mm. Final selection included 30 defects. The sites were randomly assigne d treatment with DFDBA or BDX. Soft tissue and osseous defect measurements were taken the day of surgery and 6 months post-operatively at re-entry. Av erage baseline PD, GAL, and surgical defect depth for the DFBBA group were not statistically different from the BDX group. No adverse healing response occurred. The re suits showed a statistically significant improvement in P D and AL for both materials at 6 months in 26 defects (4 defects did not re spond to therapy). Soft tissue measurements for the DFDBA group included PD reduction of 2.0+/-1.3 mm, and AL gain of 2.6+/-1.6 mm, while the BDX grou p showed a PD reduction of 3.0+/-1.7 mm, and AL gain of 3.6+/-1.8 mm. Osseo us measurements showed bone fill of 2.4 mm (46.8%,) for the DFDBA group and 3.0 mm (55.8%) for the BDX group. Defect resolution was 59.4% for the DFDB A group and 77.6% for the BDX group. Statistical analysis revealed there wa s no statistical difference be tween the 2 materials in all measurements.