A new prognostic classification for predicting survival in patients with hepatocellular carcinoma

Background/Aims: In patients with hepatocellular carcinoma, prediction of s urvival is difficult. The aim of this prospective study was to provide a si mple classification for predicting survival of patients with hepatocellular carcinoma, based on a multivariable Cox model, Methods: Seven hundred and sixty-one patients who presented with hepatocell ular carcinoma from 24 Western medical centers were enrolled over a 30-mont h period. Patients were randomly assigned to either a training sample (n=50 6, with 418 deaths) from which a classification system was established, or a test sample (n=255, with 200 deaths) for validating its prognostic signif icance. Results: Five prognostic factors were selected at the 0.0001 level: Karnofs ky index <80% (relative risk of death=2.2, 95% confidence interval: 1.7-2.7 ), serum bilirubin >50 mu mol/l (relative risk = 2.1, 95% confidence interv al: 1.7-2.6), serum alkaline phosphatase at least twice the upper limit of normal range (relative risk = 1.6, 95% confidence interval: 1.3-2.0), serum alpha-fetoprotein >35 mu g/l (relative risk = 1.7, 95% confidence interval : 1.4-2.1), and ultrasonographic portal obstruction (relative risk = 1.3, 9 5% confidence interval: 1.1-1.7), Three risk groups with different 1-year s urvival rates (72%, 34%, 7%) were derived, and independently validated in t he test sample (79%, 31%, 4%), Conclusion: This classification could be useful in the assessment of progno sis from homogeneous groups of patients with respect to their expected outc ome.