Study of the complexation of octakis(diethoxyphosphoryloxy)-tetramethylcalix[4]resorcinarene with benzene derivatives by the RP HPLC method

Stability constants of the host-guest complexes of octakis(diethoxyphosphor yloxy) tetramethylcalix[4]resorcinarene (RA) with different benzene derivat ives (alkyl benzenes, halogenated benzenes, substituted aldehydes, phenols and benzoic acids) were determined by the reversed phase high-performance l iquid chromatography (RP HPLC) method (Separon SGX C 18, UV detector at 254 nm and acetonitrile-water, 86 : 14, v/v, as mobile phase) from the relatio nship between the aromatic guest capacity factors and the RA host concentra tion in the mobile phase. The constants are within the range 17-596 M-1, de pendent on the size, nature, position and quantity of the substituents in t he benzene ring of the guest molecules.