Interaction between sulfaproxyline and beta-cyclodextrin in the solution and solid states

Authors
Szafran, B Pawlaczyk, J
Citation
B. Szafran et J. Pawlaczyk, Interaction between sulfaproxyline and beta-cyclodextrin in the solution and solid states, J INCL P MA, 34(2), 1999, pp. 131-139
Citations number
16
Categorie Soggetti
Chemistry
Journal title
JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY
ISSN journal
13883127 → ACNP
Volume
34
Issue
2
Year of publication
1999
Pages
131 - 139
Database
ISI
SICI code
1388-3127(199906)34:2<131:IBSABI>2.0.ZU;2-J
Abstract
The 1 : 1 inclusion complex between sulfaproxyline (SP) and beta-cyclodextr in (beta-CD) was prepared by the freeze-drying and the kneading method. Com plex formation was confirmed in the solid state by X-ray diffractometry and by infrared spectroscopy. The interaction between sulfaproxyline and beta- cyclodextrin in solution was studied by the solubility method and C-13-NMR spectroscopy. Phase solubility studies in water revealed a AN type diagram and a stability constant of 930 +/- 120 M-1 for a 1 : 1 inclusion complex w as derived. Complexation was found to improve the dissolution rate of sulfa proxyline.