Ethical aspects of clinical trials: the attitudes of the public and out-patients

Objectives. To investigate attitudes to clinical research amongst potential research participants, Design. Questionnaire-survey. Setting. Two medical out-patient clinics and the background population. Subjects, A total of 508 randomly selected citizens in Copenhagen County (6 4% responded) and 200 consecutive patients attending the out-patient clinic s (64% responded). Outcome measures. Attitudes toward different aspects of clinical research. Results. Positive attitudes toward medical research were disclosed. The maj ority found scientific testing necessary, although only a minority consider ed participation a moral obligation. Both personal benefits and altruistic motives for participation were highly rated, whereas former positive experi ences from trial participation had only minor impact on decisions. Several respondents stated former trial participation had changed their attitudes n egatively. Lack of feedback of results was of major importance for this cha nge. Attitudes are significantly influenced by the presence of independent research ethics committees, whereas trial technicalities such as drawing lo ts and blinding was found problematic by only a few respondents, Altruistic motives of physicians to conduct trials were highly rated by a majority of respondents, but the motive of promoting doctors' careers was also judged important. Respondents rated nondiscomforting procedures as acceptable or h aving only a small impact or strain on their. lives. Conclusion, Attitudes toward medical research are positive amongst out-pati ents and the general public. Altruistic and nonaltruistic motives both conc erning trial participation and concerning the motives of physicians to cond uct medical research were rated highly, Lack of feedback concerning results of trials to participants was important for a negative change in attitude toward participation.