Induction of Toxoplasma gondii cystogenesis and multiplication arrest by treatments with a phosphatidylcholine-specific phospholipase C inhibitor

Authors
Ricard, J Pelloux, H Gross, U Meunier, A Ambroise-Thomas, P
Citation
J. Ricard et al., Induction of Toxoplasma gondii cystogenesis and multiplication arrest by treatments with a phosphatidylcholine-specific phospholipase C inhibitor, J PARASITOL, 85(3), 1999, pp. 583-585
Citations number
19
Categorie Soggetti
Biology,Microbiology
Journal title
JOURNAL OF PARASITOLOGY
ISSN journal
00223395 → ACNP
Volume
85
Issue
3
Year of publication
1999
Pages
583 - 585
Database
ISI
SICI code
0022-3395(199906)85:3<583:IOTGCA>2.0.ZU;2-S
Abstract
A model of tissue cyst formation was developed using D609, a specific inhib itor of phosphatidylcholine specific-phospholipase C. The phospholipase inh ibitor induced a decrease in Toxoplasma gondii multiplication and several s uccessive treatments could lead to an arrest in parasite multiplication and full encystment of the parasites. This could be a first step towards an in vitro model of T. gondii reactivation.