Liposome fusion induced by pH-sensitive copolymer: Poly(4-vinylpyridine-co-N,N '-diethylaminoethyl methacrylate)

Authors
Park, JS Lim, YB Kwon, YM Jeong, B Choi, YH Kim, SW
Citation
Js. Park et al., Liposome fusion induced by pH-sensitive copolymer: Poly(4-vinylpyridine-co-N,N '-diethylaminoethyl methacrylate), J POL SC PC, 37(14), 1999, pp. 2305-2309
Citations number
15
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
ISSN journal
0887624X → ACNP
Volume
37
Issue
14
Year of publication
1999
Pages
2305 - 2309
Database
ISI
SICI code
0887-624X(19990715)37:14<2305:LFIBPC>2.0.ZU;2-U
Abstract
Copolymers of 4-vinylpyridine (4VP) or N,N'-diethylaminoethyl methacrylate (DEAEMA) were synthesized with various comonomer feed ratios (30 : 70, 50 : 50, and 70 : 30). Charge densities along the polymeric chain were changed in a pH-dependent manner. The copolymers induced membrane fusion of negativ ely charged liposomes followed by aggregation in a pH-dependent manner, whi ch was investigated by resonance energy transfer. It was found that pH-depe ndent fusion of liposomes was dependent on the composition of 4VP and DEAMA in the copolymer with the degree of protonation proportional to the differ ence in pK(a) value of the two monomers. (C) 1999 John Wiley & Sons, Inc.