Shouter courses of therapy have been developed for most antifungal agents u
sed for the treatment of vaginal candidiasis, including clotrimazole, econa
zole, isoconazole, miconazole, terconazole and fluconazole. A search of the
medical literature identified 14 studies that compared single-dose therapy
for vaginal candidiasis in nonpregnant women. These studies, conducted acc
ording to similar study designs, provided sufficient information to evaluat
e clinical and mycologic cure rates. There were few significant differences
in either the clinical or mycologic cure rates of single-dose therapy, ant
i no one therapy was consistently better than any other. Until further info
rmation is available, the choice of therapy will continue to be based on in
dividual clinician preference.