Transhepatic artery chemoembolization for liver metastases of primary retroperitoneal endodermal sinus tumor - A case report

BACKGROUND: Primary retroperitoneal endodermal sinus tumors (EST) are extre mely rare and highly Malignant. Hepatic metastases I from EST are often ver y difficult to manage and carry a dismal prognosis. Transhepatic artery che moembolization has been widely applied in primary unresectable hepatoma and had been reported to have antitumor activity for some metastatic tumors. W e report a case in which transhepatic artery chemoembolization runs employe d to control hepatic metastases from EST. CASE: A 35-year-old woman presented to our service with primary retroperito neal EST associated with multiple hepatic metastases. The patient underwent aggressive debulking surgery followed by a combination chemotherapy regime n of cisplatin, vinblastine and bleomycin. Transhepatic artery chemoemboliz ation with adriamycin, lipoidol and gelfoam runs subsequently employed to t reat hepatic metastases. CONCLUSION: The combination of transhepatic artery chemoembolization and sy stemic chemotherapy after surgical resection of primary retroperitoneal EST was effective in controlling the hepatic disease in this case.