Age-related changes in the elastic fiber network of the human splenic capsule

The structural arrangement of elastic fibers in the splenic capsule from 16 human cadavers ranging in age from 1 month to 76 years was studied by hist ologic sections stained with selective methods for elastin. In infants the elastic fibers of the splenic capsule were homogeneously intermingled with collagen fibers, an arrangement that stabilizes the capsule during spleen g rowth and enlargement. With aging, collagen fibers predominate in the outer capsular surface over elastic fibers with the latter more evident in the d eep lamina of the splenic capsule. In elderly individuals, the elastic fibe rs shorten, fragment, and thicken. The progressive decrease in the amount o f elastic fibers in the splenic capsule with aging may restrict splenic dis tention and contribute to involution of the spleen as one grows older.