Syncytial variant of nodular sclerosing Hodgkin lymphoma

We report the case history of a 31-year old woman with a rare morphologic f orm of nodular sclerosing Hodgkin disease (NSHD) termed "syncytiaI variant. " Its histologic features mimic metastatic carcinoma, thymoma, melanoma, no n-Hodgkin lymphoma and germ-cell tumor. Antigens expressed on Reed-Sternber g cells, the hallmark of Hodgkin disease, and other neoplastic cells were s creened to determine the correct diagnosis. This patient demonstrates the i mportance of using specific immunohistochemical techniques to clarify the d iagnosis of NSHD of the "syncytial variant" subtype.