Influence of physical activity on plasma insulin-like growth factor-1 and insulin-like growth factor binding proteins in healthy older women

It was examined whether physical activity could alter the bioavailability o f insulin-like growth factor-1 (IGF-1) which is dependent upon plasma IGF-1 and insulin-like growth factor binding protein (IGFBPs) levels. The potent ial role that growth hormone (GH) and insulin play in this process was also examined. Seven healthy 62-69-year-old women performed four bouts of physi cal activity on separate occasions at either a low (L; heart rate = 100 bpm ) or moderate intensity (M; heart rate = 120 bpm) for either 25 (S) or 50 ( L) min (LS, low intensity/short duration; LL, low intensity/long duration; MS, moderate intensity/short duration; ML, moderate intensity/long duration ). GH levels were elevated immediately following the physical activity from 1.3 to 2.6-fold (P < 0.05) whereas IGF-1 levels were not affected by any a ctivity condition. Plasma insulin levels decreased about 35% under all acti vity conditions (P < 0.05). Plasma levels of IGFBP-1 (BP-1) were decreased immediately following the ML (- 47%; P < 0.05) and the LL (- 21%) activity bouts and remained lower than initial values 1 h after these activity bouts (- 25 and 34%, respectively, P < 0.05). The ML exercise bout resulted in s ignificant (P < 0.05) increases in IGFBP-2 (BP-2) and IGFBP-3 (BP-3) immedi ately following activity (+ 31, and + 30%, respectively) and these binding proteins remained elevated following the activity (+ 28, and + 48%, respect ively), No relationship was found between any changes in plasma GM or insul in, and changes in plasma IGFBPs. Thus, moderate intensity physical activit y of long duration may modulate the bioavailability of IGF-1 in the elderly via alterations in BP-1, -2 and -3. However, changes in circulating levels of GH, insulin or IGF-1 do not appear to be regulating IGF-1 bioavailabilt y in response to physical activity. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.