This article discusses several of the currently used methodologies for reco
rding from brain slices. Aspects of slice preparation as well as appropriat
e uses for the various slice models (i.e., thin or thick slices) are consid
ered. The merits of extracellular and intracellular electrophysiological re
cording and their uses are discussed. In addition, mechanisms of neuronal c
ircuit activation and stimulation are presented. (C) 1999 Academic Press.