The changing landscape of ischaemic brain injury mechanisms

Authors
Lee, JM Zipfel, GJ Choi, DW
Citation
Jm. Lee et al., The changing landscape of ischaemic brain injury mechanisms, NATURE, 399(6738), 1999, pp. A7-A14
Citations number
100
Categorie Soggetti
Multidisciplinary,Multidisciplinary,Multidisciplinary
Journal title
NATURE
ISSN journal
00280836 → ACNP
Volume
399
Issue
6738
Year of publication
1999
Supplement
S
Pages
A7 - A14
Database
ISI
SICI code
0028-0836(19990624)399:6738<A7:TCLOIB>2.0.ZU;2-A
Abstract
Thrombolysis has become established as an acute treatment for human stroke. But despite multiple clinical trials, neuroprotective strategies have yet to be proved effective in humans. Here we discuss intrinsic tissue mechanis ms of ischaemic brain injury, and present a perspective that broadening of therapeutic targeting beyond excitotoxicity and neuronal calcium overload w ill be desirable for developing the most effective neuroprotective therapie s.