Selective coupling of mouse brain metabotropic sigma (sigma) receptor withrecombinant G(i1)

Authors
Tokuyama, S Hirata, K Yoshida, A Maruo, J Matsuno, K Mita, S Ueda, H
Citation
S. Tokuyama et al., Selective coupling of mouse brain metabotropic sigma (sigma) receptor withrecombinant G(i1), NEUROSCI L, 268(2), 1999, pp. 85-88
Citations number
20
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROSCIENCE LETTERS
ISSN journal
03043940 → ACNP
Volume
268
Issue
2
Year of publication
1999
Pages
85 - 88
Database
ISI
SICI code
0304-3940(19990618)268:2<85:SCOMBM>2.0.ZU;2-8
Abstract
Various sigma (a) ligands including (+)-pentazocine stimulated [S-35]GTP ga mma S binding in synaptic membranes from the mouse cerebellum. The (+)-pent azocine-stimulated [S-35]GTP gamma S binding was blocked by the treatment o f membranes with pertussis toxin (PTX), but completely recovered by the rec onstitution of PTX-treated membranes with recombinant G(11), but not with G (oA) These findings suggest that metabotropic a receptors are selectively c oupled to G(11) protein. (C) 1999 Published by Elsevier Science Ireland Ltd . All rights reserved.