Ml. Bryant et al., Comparison of the clearance of radiolabelled nose drops and nasal spray asmucosally delivered vaccine, NUCL MED C, 20(2), 1999, pp. 171-174
The distribution and nasal clearance of Tc-99(m)-labelled albumin (18.5 MBq
), used as a mucosal vaccine surrogate for FluMist(TM), was determined in t
hree volunteers. The subjects were randomized in a crossover clinical study
design to receive either large-particle aerosal (nasal spray) followed by
nose drops, or nose drops followed by the nasal spray, 1 week apart. Gamma
scintigraphy was used to measure the distribution and clearance. The 'vacci
ne' delivered as drops was cleared from the nose into the oesophagus and up
per stomach at very variable rates. In contrast, the nasal spray was unifor
mly distributed and cleared from the nasopharynx with a 50% mean clearance
time of 50 min (range 40-60 min) and was not detected in the lungs. ((C) 19
99 Lippincott Williams & Wilkins).