Prostaglandin E-2 cervical ripening without subsequent induction of labor

Objective: To determine whether outpatient administration of intracervical prostaglandin (PG) E-2 gel decreases the interval to delivery and duration of labor. Methods: A randomized, double-blind, placebo-controlled trial compared the intracervical placement of 0.5 mg PGE(2) gel with placebo in 61 pregnant wo men at 38 weeks' or greater gestation with Bishop scores less than 9. Trans vaginal cervical length, fetal fibronectin, and Bishop score were assessed before gel placement. Subjects were then allowed to go into spontaneous lab or unless an indication for induction developed. Results: Thirty women were assigned to PGE(2) and 31 to placebo. There were no significant demographic differences between the groups and there were n o differences in cervical length, fetal fibronectin status, or Bishop score s. Fifteen women in the PGE(2) group and five in the placebo group went int o labor and delivered within the first 2 days after gel placement (P = .007 ). The median interval to delivery was significantly shorter in the PGE, gr oup, at 2.5 days, compared with placebo, at 7 days (P = .02). Nulliparas in the PGE(2) group had a median interval to delivery of 2 days, compared wit h 7 days for nulliparas receiving placebo (P = .03). Active phases of labor were significantly shorter in the PGE(2) group and for women with a negati ve fetal fibronectin test who received PGE(2). Conclusion: Outpatient administration of intracervical PGE(2) gel shortened intervals to delivery and shortened labor. (C) 1999 by The American Colleg e of Obstetricians and Gynecologists.