THE TRYPANOSOMATID RIESKE IRON-SULFUR PROTEINS HAVE A CLEAVED PRESEQUENCE THAT MAY DIRECT MITOCHONDRIAL IMPORT

We have cloned the gene that encodes subunit 4 of the T. brucei cytoch rome-e reductase complex and a fragment of the C. fasciculata subunit 4 cDNA and have shown that subunit 4 is the Rieske iron-sulfur protein . The cleaved presequences of the trypanosomatid iron-sulfur proteins resemble conventional mitochondrial targeting presequences but are sma ller than other eukaryotic iron-sulfur protein signal peptides.