Bioactive sesquiterpenes from Santolina rosmarinifolia subsp, Canescens. Aconformational analysis of the germacrane ring

Authors
Barrero, AF Herrador, MM Quilez, JF Alvarez-Manzaneda, R Portal, D Gavin, JA Gravalos, DG Simmonds, MSJ Blaney, WM
Citation
Af. Barrero et al., Bioactive sesquiterpenes from Santolina rosmarinifolia subsp, Canescens. Aconformational analysis of the germacrane ring, PHYTOCHEM, 51(4), 1999, pp. 529-541
Citations number
28
Categorie Soggetti
Agricultural Chemistry","Animal & Plant Sciences
Journal title
PHYTOCHEMISTRY
ISSN journal
00319422 → ACNP
Volume
51
Issue
4
Year of publication
1999
Pages
529 - 541
Database
ISI
SICI code
0031-9422(199906)51:4<529:BSFSRS>2.0.ZU;2-0
Abstract
The hexane extract of aerial parts of Santolina rosmarinifolia subsp. canes cens afforded eight new sesquiterpenes in addition to known compounds. Thei r structures were determined by spectroscopic methods and chemical transfor mations. The conformational analysis of the germacrane constituents was car ried out by spectroscopic methods, including NMR at varying temperature and by molecular mechanics calculations. The antifeedant, antibacterial and an titumoral activity of selected compounds has been tested. (C) 1999 Elsevier Science Ltd. All rights reserved.