The stereochemistry of the preferred conformers of several 3-hydroxytetrahy
dro-1,3-oxazines has been established by NMR spectroscopy. Strong anomeric
effect stabilises the conformation having equatorial orientation of the lon
e pair on nitrogen. Nitrogen inversion process was found to be the rate lim
iting process in the conformational equilibria. (C) 1999 Elsevier Science B
.V. All rights reserved.