Synthesis of N-desmethyl derivatives of 17 alpha-acetoxy-11 beta(4-N,N-dimethylaminophenyl)-19-norpregna-4,9-diene-3,20-dione and mifepristone - Substrates for the synthesis of radioligands

Authors
Rao, PN Acosta, CK Cessac, JW Bahr, ML Kim, HK
Citation
Pn. Rao et al., Synthesis of N-desmethyl derivatives of 17 alpha-acetoxy-11 beta(4-N,N-dimethylaminophenyl)-19-norpregna-4,9-diene-3,20-dione and mifepristone - Substrates for the synthesis of radioligands, STEROIDS, 64(3), 1999, pp. 205-212
Citations number
9
Categorie Soggetti
Biochemistry & Biophysics
Journal title
STEROIDS
ISSN journal
0039128X → ACNP
Volume
64
Issue
3
Year of publication
1999
Pages
205 - 212
Database
ISI
SICI code
0039-128X(199903)64:3<205:SONDO1>2.0.ZU;2-C
Abstract
The syntheses of N-desmethyl derivatives of CDB-2914 and the mono-N-desmeth yl derivative of Mifepristone are described. We also describe the use of th e mono-desmethyl derivatives as substrates for the synthesis of N-tritometh yl derivatives of CDB-2914 and Mifepristone with high specific activity (ca . 80 Ci/mmol), which serve as radioligands for radioimmunoassay. (C) 1999 E lsevier Science Inc. All rights reserved.