Design and synthesis of constrained epothilone analogs: The efficient synthesis of eleven-membered rings by olefin metathesis

Authors
Winkler, JD Holland, JM Kasparec, J Axelsen, PH
Citation
Jd. Winkler et al., Design and synthesis of constrained epothilone analogs: The efficient synthesis of eleven-membered rings by olefin metathesis, TETRAHEDRON, 55(27), 1999, pp. 8199-8214
Citations number
40
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020 → ACNP
Volume
55
Issue
27
Year of publication
1999
Pages
8199 - 8214
Database
ISI
SICI code
0040-4020(19990702)55:27<8199:DASOCE>2.0.ZU;2-J
Abstract
The efficient synthesis of both left- and right-hand halves of a constraine d analog of the anticancer natural product epothilone is described. The ele ven-membered rings common to both compounds are prepared by olefin metathes is. (C) 1999 Elsevier Science Ltd. All rights reserved.