Myocardial dyssynergy does not necessarily indicate myocardial necrosi
s in patients with coronary artery disease. The differentiation betwee
n viable and non-viable tissue is of great clinical importance in orde
r to make the most appropriate clinical decision in the individual pat
ient. Several techniques are used to assess myocardial viability. Nucl
ear medicine gives reliable information on regional perfusion, metabol
ism and cell membrane integrity, while echocardiography provides real
time visualization of myocardial thickening in basal conditions and co
ntinuously during pharmacological interventions. The presence or absen
ce of contractile reserve in akinetic regions can be evaluated by phar
macological stress echocardiography. This article presents the semiolo
gy of myocardial viability as characterized by these different methods
and reviews their relative value in different clinical settings.