3N-METHYLBIPHENYLSULFONYLUREA AND SULFONYLUREA-CARBAMATE SUBSTITUTED IMIDAZO[4,5-B]PYRIDINES - POTENT ANTAGONISTS OF THE ANG-II AT(1) RECEPTORS

Authors
HEITSCH H BECKER RHA KLEEMANN HW WAGNER A
Citation
H. Heitsch et al., 3N-METHYLBIPHENYLSULFONYLUREA AND SULFONYLUREA-CARBAMATE SUBSTITUTED IMIDAZO[4,5-B]PYRIDINES - POTENT ANTAGONISTS OF THE ANG-II AT(1) RECEPTORS, Bioorganic & medicinal chemistry, 5(4), 1997, pp. 673-678
Citations number
13
Categorie Soggetti
Biology,"Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry → ACNP
ISSN journal
09680896
Volume
5
Issue
4
Year of publication
1997
Pages
673 - 678
Database
ISI
SICI code
0968-0896(1997)5:4<673:3ASSI>2.0.ZU;2-R
Abstract
The synthesis and the SAR study of imidazo[4,5-b]pyridine biphenyl sul fonylureas and -carbamates as highly potent AT(1)-selective ANG II rec eptor antagonists are described. Several members of this new class of antagonists efficiently inhibited the ANG II-induced presser response in pithed rats after iv and intraduodenal (id) administration. (C) 199 7 Elsevier Science Ltd.