Impact of delta-9-tetrahydrocannabinol and metabolites on the immune system

Many studies obvious impact of cannabinoids on the immune system. These stu dies follow the rapid advanced researches led in the immunology field. D9 T etrahydrocannabinol and their metabolites decrease production of tumoral ne crosis factor alpha. This decrease has for consequence a decrease of the ap optosis. Recent discovery of implication of cytokines in the phenomena of d ependence, make the cannabis and their metabolites promoting agent induced dependence in association with drug abuse. The withdrawal of these products necessitates a intact immune system. D9 Tetrahydrocannabinnol and their metabolites inhibit production of IL-1 a nd gamma interferon. This inhibition has for consequence a decrease of 33% of the lymphocytes activity and an inhibition of 66% of the lymphocytes ade nyl cyclase activity. The consumption of cannabis decreases immunological competence of macrophag es, and alterate their essential role of trophicity of the nervous central system. Furthermore, inhibiting actions of cannabinoids on the cyclo-oxygenase, pro mote production of arachidonic acid degradation products. This compounds mi mic the action of histamine, and inducing a raise of the vascular permeabil ity and bronchospasm. These molecules contributes at delayed reaction of an aphylaxia. However these actions of cannabinoids on the immune system promote their pu ll-back in cure of new pathology likes AIDS.