A FACILE ENZYMATIC PROCESS FOR THE PREPARATION OF (S)-NAPROXEN ESTER PRODRUG IN ORGANIC-SOLVENTS

Authors
CHANG CS TSAI SW
Citation
Cs. Chang et Sw. Tsai, A FACILE ENZYMATIC PROCESS FOR THE PREPARATION OF (S)-NAPROXEN ESTER PRODRUG IN ORGANIC-SOLVENTS, Enzyme and microbial technology, 20(8), 1997, pp. 635-639
Citations number
17
Categorie Soggetti
Biothechnology & Applied Migrobiology
Journal title
Enzyme and microbial technology → ACNP
ISSN journal
01410229
Volume
20
Issue
8
Year of publication
1997
Pages
635 - 639
Database
ISI
SICI code
0141-0229(1997)20:8<635:AFEPFT>2.0.ZU;2-X
Abstract
A facile enzymatic synthesis process has been developed to directly pr epare the 4-morpholinoethyl ester prodrug of (s)-Naproxen from racemic Naproxen using lipases as the biocatalysts in the organic solvent. Wi th the careful selection of lipase (Lipase MY) and reaction medium (cy clohenane), a high enantiomeric ratio of 136 for the enzyme was obtain ed. A Ping-Pong Bi Bi mechanism with competitive inhibition by the alc ohol was illustrated from the variation of initial rates with substrat e concentrations. (C) 1997 by Elsevier Science Inc.