QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP STUDIES ON SOME ANTI-HUMAN-IMMUNODEFICIENCY-VIRUS-1 (ANTI-HIV-1) DRUGS - VIRAL REVERSE-TRANSCRIPTASE INHIBITORS

The anti-HIV-1 activity of some 3-[(benzoxazol-2-ylmethyl)amino]-, 3-[ (benzoxazol-2-yl)ethyl]-, 3-[N-(phthalimidomethyl)amino] - and 3-[N-(p hthalimido)ethyl]-5-ethyl-6-methyl pyridin-2(1H)-one derivatives, that have been found to elicit their action through the allosteric inhibit ion of the enzyme viral reverse transcriptase (VRT), have been analyse d in relation to the physicochemical properties of the molecules. Sign ificant correlations were obtained between the activity and the hydrop hobic and electronic constants of substituents and van der Waals' volu me of the linker chain. Based on these findings the mechanism of actio n of these drugs is discussed.