Experimental results and preliminary clinical experience with synthetic rea
bsorbable materials in chest wall reconstruction are reported. Six beagle d
ogs underwent chest wall resection involving three or four consecutive ribs
. Reparative procedure was performed by construction of a polydioxanone-ban
d grid, anchored to the adjacent undamaged ribs. A mild wound infection dev
eloped in 1 animal but resolved without rejection of the prosthesis. The ex
perimental material has shown favorable properties, both mechanical and bio
logical. Subsequently, 11 patients, with different indications, underwent r
econstructive procedures of the chest wall with reabsorbable prostheses. No
complications have occurred. Long-term stability was excellent in all pati
ents, with a mean follow-up longer than 6 months. The advantages of reabsor
bable compounds are pointed out along with the possible applications for ch
est wall reconstruction after chest wall resection.