Background. In 1986 we introduced the technique of antegrade selective perf
usion of the brain with cold blood during surgery of the aortic arch.
Methods. Between January 1984 and March 1998, 171 patients (118 males and 5
3 females) aged 25 to 83 years (mean 56.5 +/- 17), underwent replacement of
the transverse aortic arch with the aid of cold blood antegrade selective
perfusion. One hundred twenty two patients (71.3%) with chronic lesions wer
e operated on electively; 49 patients (28.6%) were operated on urgently for
acute aortic dissection (42 patients) or for a ruptured chronic aneurysm (
7 patients). Fifty-one patients (29.8%) had previously undergone a surgical
procedure on the thoracic aorta. Mean duration of cardiopulmonary bypass w
as 121 minutes (range: 65-248); mean duration of cerebral perfusion was 60
minutes (range: 15-90), and mean duration of systemic circulatory arrest ci
rcuit was 32 minutes (range: 10-57). The electroencephalogram, routinely re
corded, showed disappearance of electrical activity in a mean of 9 minutes
(range: 3-16) initial return of electrical activity after a mean of 12 minu
tes (range: 1-35) and normalization in a mean time of 66 minutes.
Results. All patients but 7 (4%) showed signs of normal awakening within 8
hours postoperatively. Six patients (3.5%) had fatal neurologic complicatio
ns, and 16 patients (9.3%) had a non-fatal neurologic complications. Twenty
-nine patients (16.9%) died during the postoperative hospital course. There
was a significant difference between patients aged less than 60 years (9%)
and patients older than 60 years (mortality rate 26.4%, p < 0.02). There w
as also a significant difference between patients undergoing an isolated re
placement of the arch, and those in whom the replacement was extended to th
e descending aorta in whom mortality was 36.4% (chi(2), p < 0.02). Lesion a
nd gender had no significant influence on the outcome of the patients, nor
had the duration of cardiopulmonary bypass, circulatory arrest, and cerebra
l perfusion. In particular, no correlation could be established between the
duration of cerebral perfusion and the occurrence of neurologic complicati
ons.
Conclusion. The clinical results obtained throughout this experience have d
emonstrated that selective antegrade cerebral perfusion with cold blood pro
vides excellent protection during surgery of the transverse aortic arch. In
addition, it avoids the use of deep hypothermia and prolonged cardiopulmon
ary bypass and does not limit the time allowed to perform the aortic repair
. In our opinion it is the technique of choice, especially in frail patient
s or those requiring a long and difficult procedure. (C) 1999 by The Societ
y of Thoracic Surgeons.