Determination of the drug naphazoline in pharmaceutical preparations by heavy atom-induced room-temperature phosphorescence

A simple, selective, and sensitive heavy atom-induced room-temperature phos phorimetric method (HAI-RTP) is described for the determination of naphazol ine (NPZ) in pharmaceutical preparations. The phosphorescence signals are a consequence of intermolecular protection when analytes are, exclusively, i n the presence of a heavy atom salt and sodium sulfite as an oxygen scaveng er to minimize RTP quenching. This variable selection constitutes the basis of the HAI-RTP method for the determination of naphazoline (detection limi t 43.5 ng/mL; 2.39% relative standard deviation at 500 ng/mL), The method h as been applied to the analysis of pharmaceutical preparations.