R. Motta et Jp. Louis, Audiogenic seizure sensitivity in mouse lines genetically selected for high versus low blood magnesium levels, BEHAV GENET, 29(2), 1999, pp. 125-130
The MGH and MGL mouse lines, genetically selected for high and low blood ma
gnesium (Mg) levels, respectively, exhibit marked differences for character
istics expected to be related to blood Mg levels, such as increased stress
sensitivity and stress-induced aggressivity in MGL mice. However, although
Mg deficiency experimentally induced by low oral Mg intake has been shown p
reviously to increase susceptibility to audiogenic seizures, MGL were less
sensitive to audiogenic seizures than MGH mice. The MGH-MGL lines may, ther
efore, provide a beneficial and complementary model for the study of the re
lationships between audiogenic seizures and blood Mg levels.