Increased stability of peptidesulfonamide peptidomimetics towards proteasecatalyzed degradation

Authors
de Bont, DBA Sliedregt-Bol, KM Hofmeyer, LJF Liskamp, RMJ
Citation
Dba. De Bont et al., Increased stability of peptidesulfonamide peptidomimetics towards proteasecatalyzed degradation, BIO MED CH, 7(6), 1999, pp. 1043-1047
Citations number
19
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY
ISSN journal
09680896 → ACNP
Volume
7
Issue
6
Year of publication
1999
Pages
1043 - 1047
Database
ISI
SICI code
0968-0896(199906)7:6<1043:ISOPPT>2.0.ZU;2-T
Abstract
Replacement of amide bonds in peptides by sulfonamide moieties resulted in peptidosulfonamides with an increased stability towards protease catalyzed degradation. In addition to protection of the protease cleavage site, it wa s found that introduction of a sulfonamide also influenced the stability of adjacent amide bonds. (C) 1999 Elsevier Science Ltd. All rights reserved.