Am. Deshpande et al., Synthesis and screening of a combinatorial library of naphthalene substituted chalcones: Inhibitors of leukotriene B-4, BIO MED CH, 7(6), 1999, pp. 1237-1240
A combinatorial mini library of naphthalene substituted chalcones has been
prepared by solution phase chemistry. Screening of these mixtures for leuko
triene Bq inhibitory activity using human whole blood assay (HWBL) afforded
a lead compound, 1-(6-butoxy-2-naphthyl)-3-(4-nitrophenyl)-prop-2-en-1-one
(K(4)A(3)) with an IC50 value of 18.5 mu M. (C) 1999 Elsevier Science Ltd.
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