Sequential hepatic and pulmonary resections for metastatic colorectal cancer

Background: Resection of pulmonary or hepatic colorectal metastases is asso ciated with a 5-year survival rate of 25-40 per cent. This report analyses outcome following sequential resection of colorectal metastases to both org ans. Methods: Seventeen patients with histologically confirmed colorectal adenoc arcinoma and resection of liver and lung metastases were identified from a prospective database. Results: The median interval between resection of the primary tumour and fi rst metastasis was 21 (range 0-64) months. The interval between resection o f the first and subsequent metastases was 18 (range 1-74) months. No patien t died in the postoperative period and there were two perioperative complic ations. The overall survival rate in 17 patients was 70 per cent at 2 years from resection of metastasis to the second organ, but the disease-free sur vival rate at 2 years was only 24 per cent. Conclusion: Although few long-term survivors were observed in this small se ries, sequential resection of hepatic and pulmonary metastases is warranted in a highly selected group of patients.