Validation of self-reported transfusion histories in renal dialysis patients

The purpose of this analysis was to assess the validity of self-reported tr ansfusion histories in dialysis patients. Using data from a cross-sectional study of a dialysis population being investigated for hepatitis C virus (H CV) infection, the correspondence between self-reported transmission histor y and transfusion records was explored. Demographic data and dialysis histo ries were examined in relation to the accuracy of self-reports. Overall, th e questionnaire data and the blood bank records agreed for 89% of participa nts. The Kappa statistic was 0.72 (95% CI: 0.61, 0.83) indicating an accept able level of agreement. The effect of non-differential exposure misclassif ication on the risk estimates for transfusion history an a determinant of H CV infection is demonstrated. Exploring the discrepancies between self-repo rts and documented transfusion histories underlines the need to communicate clearly medical interventions in chronically ill patients. Additionally, i t suggests that studies into transfusion-acquired blood-borne pathogens sho uld use all available information sources to establish exposure.