DNA mismatch repair deficiency in curatively resected sextuple primary cancers in different organs: a molecular case report

A male patient synchronously or metachronously underwent six curative resec tions after diagnoses of cancers in the rectum, urinary bladder, stomach, c olon, liver and lung. Five cancers, excluding early colon cancer, were anal yzed for instability in seven microsatellite markers and in transforming gr owth factor beta type II receptor, insulin-like growth factor II receptor a nd BAX. All analyzed cancers had replication errors and instability in at l east one target gene. These results suggest that abnormal DNA mismatch repa ir system plays a major role in the occurrence of multiple primary cancers in this case. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.