Citation
F. Iglesias-guerra et al., Alkylating agents from sugars. Alkyl hexopyranoside derivatives as carriersystems for chlorambucil, CARBOHY RES, 316(1-4), 1999, pp. 71-84
Citations number
17
Categorie Soggetti
Agricultural Chemistry","Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
CARBOHYDRATE RESEARCH
ISSN journal
00086215
→ ACNP
Volume
316
Issue
1-4
Year of publication
1999
Pages
71 - 84
Database
ISI
SICI code
0008-6215(19990331)316:1-4<71:AAFSAH>2.0.ZU;2-#
Abstract
Chlorambucil derivatives involving alkyl 2-aminodeoxy sugars have been synt
hesized in good yield by coupling the chlorambucil moiety to positions C-2
or C-3 of the sugar, directly or via a spacer. The starting material was ea
sily available from 2-acetamido-2-deoxy-D-glucose. The final compounds were
tested for cytotoxicity, and some of those that presented the best results
were studied for inhibition of cell proliferation. (C) 1999 Elsevier Scien
ce Ltd. All rights reserved.