Fjr. Abadi et al., In vitro activities of meropenem and other antimicrobial agents against British meningococcal isolates, CHEMOTHERA, 45(4), 1999, pp. 253-257
The in vitro activity of meropenem was compared with those of penicillin, a
mpicillin, cefuroxime, cetriaxone, cefotaxime, rifampicin, chloramphenicol,
sulphadiazine and ciprofloxacin against 121 British meningococcal isolates
by a microdilution method in Mueller-Hinton broth and by the E test. All m
eningococcal strains were susceptible to the agents except for ampicillin (
88.4%), penicillin (88.4%), sulphadiazine (57.9%) and rifampicin (95%). The
emergence of resistance problems among meningococcal isolates stresses the
need for their constant monitoring and of the development of new agents. I
n this study we have shown that meropenem is highly active in vitro against
Neisseria meningitidis. Recent studies have indicated that meropenem is hi
ghly active clinically and bacteriologically in the treatment of bacterial
meningitis. Thus, the potentials of meropenem as meningococcal prophylactic
and therapeutic agent needs to be fully evaluated.