Isoniazid induced pellagra despite pyridoxine supplementation

Authors
Darvay, A Basarab, T McGregor, JM Russell-Jones, R
Citation
A. Darvay et al., Isoniazid induced pellagra despite pyridoxine supplementation, CLIN EXP D, 24(3), 1999, pp. 167-169
Citations number
11
Categorie Soggetti
Dermatology
Journal title
CLINICAL AND EXPERIMENTAL DERMATOLOGY
ISSN journal
03076938 → ACNP
Volume
24
Issue
3
Year of publication
1999
Pages
167 - 169
Database
ISI
SICI code
0307-6938(199905)24:3<167:IIPDPS>2.0.ZU;2-Z
Abstract
Although pellagra is a recognized complication of isoniazid therapy, the di agnosis may be overlooked or delayed - sometimes with life-threatening cons equences. We report a case of isoniazid-induced pellagra which occurred des pite pyridoxine supplementation. Drug withdrawal and supplementation with n iacin led to a rapid and sustained clinical improvement. The possible mecha nisms of isoniazid induced pellagra are discussed.