J. Wohlfahrt et M. Melbye, Maternal risk of breast cancer and birth characteristics of offspring by time since birth, EPIDEMIOLOG, 10(4), 1999, pp. 441-444
Citations number
25
Categorie Soggetti
Envirnomentale Medicine & Public Health","Medical Research General Topics
We examined the association between birth characteristics of offspring and
the subsequent maternal risk of breast cancer in a population-based cohort
of 998,499 women; 13 to 48 years of age at entry. There were 9,495 incident
cases of breast cancer during 12.8 million person-years of follow-up among
these women. Compared with mothers of singleton infants, mothers having a
multiple birth had an increased risk of breast cancer in the first 5 years
after a birth (relative risk (RR) = 1.8; 95% confidence interval (CI) = 1.1
-2.8). The risk for mothers having a heavy weighted child (>3.75 kg), as co
mpared with a child of light weight (less than or equal to 3 kg), was also
slightly increased (RR = 1.2; 95% CI = 0.9-1.5). This latter effect was pri
marily due to an increased incidence of tumors larger than 2 cm at diagnosi
s (RR = 1.4; 95% CI = 0.9-1.9). Our findings are compatible with the hypoth
esis that the hormonal level during pregnancy influences the risk of breast
cancer in the early years after delivery.