Lack of polymorphism of the conversion of losartan to its active metabolite E-3174 in extensive and poor metabolizers of debrisoquine (cytochrome P450 2D6) and mephenytoin (cytochrome P4502C19)

Objective: Losartan was given to subjects with known phenotypes of the poly morphic enzymes CYP2D6 and CYP2C19 to study any possible influence on the m etabolism of the drug. Methods: Plasma concentrations of losartan and E-3174 were studied after or al intake of 50 mg losartan in 24 healthy, male, Swedish Caucasian subjects who were extensive or poor metabolizers (EM/PM) of debrisoquine [cytochrom e P450 2D6 (CYP2D6)] or mephenytoin [cytochrome P450 2C19 (CYP2C19)]. Results: The areas under the curve (AUC(infinity)) of losartan and E-3174 d id not differ between poor and extensive metabolizers of debrisoquine or me phenytoin, respectively. Conclusion: About 14% of the antihypertensive drug losartan is metabolized to the active carboxylic acid metabolite E-3174, which contributes to the e ffect of losartan. The present study suggests that CYP2D6 and CYP2C19 are n ot involved to any major extent in the in vivo conversion of losartan to E- 3174.