Prefrontal-basal ganglia pathways are involved in the learning of arbitrary visuomotor associations: a PET study

Primates can learn to associate sensory cues with particular movements acco rding to arbitrary rules. We used positron emission tomography (PET) to stu dy the neural network involved in learning such arbitrary associations by t rial and error. Ten subjects were scanned at four different stages of learn ing a visuomotor conditional task (VC). The subjects were required to assoc iate four different visual patterns, presented one at a time, with four dif ferent finger movements. Scan I was acquired during initial learning. Scans 2, 3 and 4 were performed after further interscan training periods of 1, 3 and 5 min. In order to control for non-specific time effects that could ha ve confounded the learning-related rCBF changes, we also acquired four sens ory-matched control scans, in which no movements were performed. In order t o evaluate changes over time that were specific to learning the association of visual cues with movements, we acquired four scans during the learning of a motor sequence task. The statistical model tested with SPM considered both main effects of tasks and task x time interactions independently for e ach of the three experimental conditions. The right lingual gyrus and the l eft parahip-pocampal cortex increased their activity over scans in the VC t ask as compared to the sensory control. The right inferior frontal sulcus, the body of the caudate nucleus and a left cingulate motor area were specif ically implicated in learning the VC task, showing task x time interactions with the motor sequence task. These findings suggest that the learning pro cess involves a distributed network in the ventral extrastriate and prefron tal cortex, in association with the basal ganglia and the parahippocampal g yrus.