Chronic inflammatory demyelinating polyneuropathy presenting with headacheand papilledema

Chronic inflammatory demyelinating polyneuropathy is a disorder typified cl inically by motor and sensor? neuropathy of at least 2 months' duration and pathologically by multifocal inflammatory demyelination, Its usual present ation is with features reflecting the polyneuropathy namely limb weakness w ith hyporeflexia or areflexia and sensory symptoms of glove and stocking di stribution. In this report, we detail the course of a 53-year-old man who presented to our neurological service with a severe headache in association with papille dema, The initial diagnosis considered was of possible primary intracranial pathology. Two months later, he developed limb weakness and sensory sympto ms typical of chronic inflammatory demyelinating polyneuropathy. His headac he, papilledema, and limb symptoms responded to oral corticosteroid therapy , the standard treatment for this type of neuropathy. Pie hypothesize that his headache and papilledema were due to the elevated cerebrospinal fluid p rotein level as a result of the polyneuropathy, To our knowledge, this is t he first report of headache being a prominent and early symptom of this dis order.