LIPASE-CATALYZED ENANTIOSELECTIVE HYDROLYSIS OF BIS(ACYLOXYMETHYL) 1,4-DIHYDRO-3,5-PYRIDINEDICARBOXYLATES LEADING TO OPTICALLY-ACTIVE MEDICINES

Authors
EBIIKE H MARUYAMA K YAMAZAKI Y HIROSE Y KARIYA K SASAKI I KURONO Y TERAO Y ACHIWA K
Citation
H. Ebiike et al., LIPASE-CATALYZED ENANTIOSELECTIVE HYDROLYSIS OF BIS(ACYLOXYMETHYL) 1,4-DIHYDRO-3,5-PYRIDINEDICARBOXYLATES LEADING TO OPTICALLY-ACTIVE MEDICINES, Chemical and Pharmaceutical Bulletin, 45(5), 1997, pp. 863-868
Citations number
26
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
45
Issue
5
Year of publication
1997
Pages
863 - 868
Database
ISI
SICI code
0009-2363(1997)45:5<863:LEHOB1>2.0.ZU;2-T
Abstract
Chiral ,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylates and 1,4-dihy dro-2, 1,6-trimethyl-3,5-pyridinedicarboxylate have been obtained in 8 0-99%ee by lipase-catalyzed hydrolysis of bis(acyloxymethyl) dihydro-3 ,5-pyridinedicarboxylate in an H2O/organic solvent system. These chira l dihydropyridines were readily converted into chiral drugs, such as n icardipine, felodipine and PCA 4248.