STEREOCHEMISTRY OF -CYANO-T-3-METHOXY-1,2,3,4-TETRAHYDROISOQUINOLINESFROM ISOQUINOLINE REISSERT COMPOUNDS

Authors
SUGIURA M ASAI K HAMADA Y HATANO K KURONO Y SUEZAWA H HIROTA M
Citation
M. Sugiura et al., STEREOCHEMISTRY OF -CYANO-T-3-METHOXY-1,2,3,4-TETRAHYDROISOQUINOLINESFROM ISOQUINOLINE REISSERT COMPOUNDS, Chemical and Pharmaceutical Bulletin, 45(5), 1997, pp. 928-931
Citations number
23
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
45
Issue
5
Year of publication
1997
Pages
928 - 931
Database
ISI
SICI code
0009-2363(1997)45:5<928:SO->2.0.ZU;2-A
Abstract
Treatment of 2-acyl (or sulfonyl)-1-cyano-1,2-dihydroisoquinolines wit h bromine and CH3OH gave 2-acyl (or sulfonyl)-4-bromo-1-cyano-3-methox y-1,2,3,4- tetrahydroisoquinolines in a highly stereoselective manner in high yields, The stereochemistry, with 1,4-cis and 3,4-trans config urations, was determined by X-ray crystallography.