SEX-HORMONE RECEPTORS OF HEMANGIOMAS IN CHILDREN

Objective To investigate whether or nor estrogen receptor and other se x hormone receptors are present in hemangioma tissues of children. Met hods Fifty-two specimens of hemangiomas were taken from 52 children. T he specimens were doubly stained with hematoxylin-eosin and enzyme-lin king affinity immunohistochemistry. The prepared tissue slides were ob served under the microscope to search for estrogen receptors (ER), pro gestogen receptors (PR) and androgen receptors (AR) in all the cells. Results ER, PR and AR were detected in various kinds of hemangiomas. T he mean positive cell rate of each sex hormone receptor in different h emangioma tissues revealed no significant distinction in statistics (P > 0.05). Conclusions The results suggest that hemangiomas are one of the target tissues of estrogen. Estrogen, ER, PR and AR may play an im portant role in the growth and development of hemangiomas.