Cerebral cryptococcomas in an adolescent with X-linked agammaglobulinemia

Cryptococcus neoformans is an encapsulated yeast which can cause life-threa tening central nervous system (CNS) infections in humans. Cryptococcosis fr equently occurs in individuals with impaired cellular immunity, such as tho se with AIDS and those receiving immunosuppressive therapy, but it has only rarely been reported in patients with deficient humoral immunity. Cryptoco ccal infection of the CNS has not been reported in an individual with X-lin ked agammaglobulinemia (XLA). We present the case of an adolescent who deve loped multiple cerebral cryptococcomas while receiving monthly intravenous immunoglobulin for XLA.