Hemolytic uremic syndrome associated with immunoglobulin A nephropathy: A case report and review of cases of hemolytic uremic syndrome with glomerular disease

A 35-year-old man with immunoglobulin A (IgA) nephropathy who developed hem olytic uremic syndrome (HUS) presented with transient elevation of serum cr eatinine, thrombocytopenia, and hemolytic anemia with fragmented red cells with nephrotic syndrome. Hemolytic anemia and the temporarily deteriorated renal function were improved after hemodialysis and plasma exchange. Histol ogical findings were consistent with HUS and IgA nephropathy, Including thi s case, we reviewed the cases of HUS accompanied by glomerular diseases rep orted from 1969 to 1996, Surprisingly, most cases showed nephrotic syndrome at the onset of HUS, Several possible relationships between HUS and nephro tic syndrome are discussed.