Lack of association between HLA DQB1 alleles with HPV infection and histology findings in cervical cancer in Australian women

The association of human leukocyte antigen (HA) types with cervical cancer and human papillomavirus (HPV) infection is controversial. In this study we examined 186 Australian women who had biopsyconfirmed cervical cancer and detected HLA DQB1 alleles and HPV DNA, using the polymerase chain reaction (PCR) amplification and sequence specific oligonucleotides probe (SSOP) hyb ridization methods. We analyzed the frequencies of 11 DQB1 alleles accordin g to HPV DNA status (HPV positivity and HPV genotyping) and histology (tumo r type, staging, grades, lymphocyte infiltration and nodal status). No sign ificant differences among these 11 HLA DQB1 alleles were found with respect to HPV status and histology.